EducationB.S., Agricultural Science, Purdue, W. Lafayette, IN, 1977.M.S., Animal Science, Purdue, W. Lafayette, IN, 1979. Ph.D., Nutritional Biochemistry, Cornell, Ithaca, NY, 1982.ResearchMy research encompasses three interrelated areas. First, my students, colleagues and I examine the impact of an immune response against infectious diseases on growth and reproduction. We are interested in identifying the cytokines and hormones that the immune system releases in order to direct nutritional resources towards defense instead of growth and reproduction. We would also like to quantify the nutritional costs of these immune defenses. Second, we are investigating the impact of an animal’s diet on the immune response. Nutrition is clearly an important regulator of immune responses and our research is directed toward understanding the underlying mechanisms. Third, we are exploring the diverse nutritional and immune strategies of carnivorous, nectarivorous, herbivorous and granivorous animals.克莱欣博士的研究发表论文Buyse, Johan; Swennen, Quirine; Niewold, Theo A., et al.Dietary L-carnitine supplementation enhances the lipopolysaccharide-induced acute phase protein response in broiler chickensVeterinary Immunology and Immunopathology 118 (1-2) : 154-159 JUL 15 20072. Cave, Nicholas J.; Backus, Robert C.; Marks, Stanley L., et al.Modulation of innate and acquired immunity by an estrogenic dose of genistein in gonadectomized catsVeterinary Immunology and Immunopathology 117 (1-2) : 42-54 MAY 15 20073. Koutsos, Elizabeth A.; Garcia Lopez, Juan Carlos; Klasing, Kirk C.Maternal and dietary carotenoids interactively affect cutaneous basophil responses in growing chickens (Gallus gallus domesticus)Comparative Biochemistry and Physiology Part B Biochemistry & Molecular Biology 147 (1) : 87-92 MAY 20074. Millet, Sam; Bennett, Jennie; Lee, Kelly A., et al.Quantifying and comparing constitutive immunity across avian speciesDevelopmental & Comparative Immunology 31 (2) : 188-201 20075. McGraw, Kevin J.; Klasing, Kirk C.Carotenoids, immunity, and integumentary coloration in red junglefowl (Gallus gallus)Auk 123 (4) : 1161-1171 OCT 20066. Matson, Kevin D.; Tieleman, B. Irene; Klasing, Kirk C.Capture stress and the bactericidal competence of blood and plasma in five species of tropical birdsPhysiological and Biochemical Zoology 79 (3) : 556-564 MAY-JUN 20067. Selvaraj, Ramesh K.; Klasing, Kirk C.Lutein and eicosapentaenoic acid interact to modify iNOS mRNA levels through the PPAR gamma/RXR pathway in chickens and HD11 cell linesJournal of Nutrition 136 (6) : 1610-1616 JUN 20068. Koutsos, Elizabeth A.; Garcia Lopez, Juan Carlos; Klasing, Kirk C.Carotenoids from in ovo or dietary sources blunt systemic indices of the inflammatory response in growing chicks (Gallus gallus domesticus)Journal of Nutrition 136 (4) : 1027-1031 APR 20069. Matson, Kevin D.; Cohen, Alan A.; Klasing, Kirk C., et al.No simple answers for ecological immunology: relationships among immune indices at the individual level break down at the species level in waterfowlProceedings of the Royal Society Biological Sciences Series B 273 (1588) : 815-822 APR 7 200610. Humphrey, Brooke D.; Stephensen, Charles B.; Calvert, Chris C., et al.Lysine deficiency and feed restriction independently alter cationic amino acid transporter expression in chickens (Gallus gallus domesticus)Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology 143 (2) : 218-227 FEB 200611. Humphrey, Brooke D.; Klasing, Kirk C.The acute phase response alters cationic amino acid transporter expression in growing chickens (Gallus gallus domesticus)Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology 142 (4) : 485-494 DEC 200512. Klasing, Kirk C.Potential impact of nutritional strategy on noninvasive measurements of hormones in birdsWorkshop on Analysis of Hormones in Dropping of Birds and Optimality in Bird Migration, October 20 -23, 2004 , Seewiesen, GERMANYAnnals of the New York Academy of Sciences : 5-16 200513. Tieleman, B. Irene; Dijkstra, Thomas H.; Williams, Joseph B., et al.Innate immunity is a component of the pace-of-life syndrome in tropical birds5th Concerence of the European-Ornithologists-Union, 200508,, Strasbourg, FRANCEAlauda 73 (3) : 272-273 200514. Selvaraj, Ramesh Kumar; Klasing, Kirk C.Lutein and fatty acids interact to modify PPAR gamma, RXR alpha, iNOS mRNA and nitrite production in HD11 macrophage cell linesExperimental Biology 2005 Meeting/35th International Congress of Physiological Sciences, March 31 -April 06, 2005, San Diego, CA, USAFASEB Journal 19 (4, Suppl. S, Part 1) : A776 MAR 4 200515. Tieleman, B. Irene; Williams, Joseph B.; Ricklefs, Robert E., et al.Constitutive innate immunity is a component of the pace-of-life syndrome in tropical birdsProceedings of the Royal Society Biological Sciences Series B 272 (1573) : 1715-1720 AUG 22 200516. Matson, Kevin D.; Ricklefs, Robert E.; Klasing, Kirk C.A hemolysis-hemagglutination assay for characterizing constitutive innate humoral immunity in wild and domestic birdsDevelopmental & Comparative Immunology 29 (3) : 275-286 200517. Klasing, Kirk C.The costs of immunityActa Zoologica Sinica 50 (6) : 961-969 December 200418. Humphrey, Brooke D.; Stephensen, Charles B.; Calvert, Chris C., et al.Glucose and cationic amino acid transporter expression in growing chickens (Gallus gallus domesticus)Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology 138 (4) : 515-525 August 200419. Humphrey, Brooke D.; Calvert, Chris C.; Klasing, Kirk C.The ratio of full length IgY to truncated IgY in immune complexes affects macrophage phagocytosis and the acute phase response of mallard ducks (Anas platyrhynchos)Developmental & Comparative Immunology 28 (7-8) : 665-672 June 200420. Matson, Kevin D.; Millam, James R.; Klasing, Kirk C.Cockatiels (Nymphicus hollandicus) reject very low levels of plant secondary compounds.Applied Animal Behaviour Science 85 (1-2) : 141-156 12 January, 200421. Wang, Ruizhong; Millam, James R.; Klasing, Kirk C.Distribution of interleukin-1 receptor in chicken and quail brain.Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology 136A (3) : 663-671 November 200322. Koutsos, Elizabeth A.; Calvert, C. Christopher; Klasing, Kirk C.The effect of an acute phase response on tissue carotenoid levels of growing chickens (Gallus gallus domesticus).Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology 135A (4) : 635-646 August 200323. Koutsos, Elizabeth A.; Tell, Lisa A.; Woods, Leslie W., et al.Adult cockatiels (Nymphicus hollandicus) at maintenance are more sensitive to diets containing excess vitamin A than to vitamin A-deficient diets.Journal of Nutrition 133 (6) : 1898-1902 June 200324. Koutsos, Elizabeth A.; Calvert, Chris C.; Humphrey, Brooke David, et al.Interactions between carotenoids and the inflammatory response in chickens.FASEB Meeting on Experimental Biology: Translating the Genome, April 11-15, 2003, San Diego, CA, USAFASEB Journal 17 (4-5) : Abstract No. 699.1 March 200325. Humphrey, Brooke David; Calvert, Chris C.; Stephensen, Charles, et al.Effect of the acute phase response on cationic amino acid transporter expression in lysine deficient chicks.FASEB Meeting on Experimental Biology: Translating the Genome, April 11-15, 2003, San Diego, CA, USAFASEB Journal 17 (4-5) : Abstract No. 697.2 March 200326. Sijben, John W. C.; Klasing, Kirk C.; Schrama, Johan W., et al.Early in vivo cytokine genes expression in chickens after challenge with Salmonella typhimurium lipopolysaccharide and modulation by dietary n - 3 polyunsaturated fatty acids.Developmental & Comparative Immunology 27 (6-7) : 611-619 June-July 200327. Koutsos, Elizabeth A.; Clifford, Andrew J.; Calvert, C. Christopher, et al.Maternal carotenoid status modifies the incorporation of dietary carotenoids into immune tissues of growing chickens (Gallus gallus domesticus).Journal of Nutrition 133 (4) : 1132-1138 April 200328. Koutsos, Elizabeth A.; Calvert, C. Christopher; Klasing, Kirk C.Incorporation of dietary carotenoids into immune tissues of growing chicks is determined by initial yolk carotenoid concentrationAnnual Meeting of the Professional Research Scientists on Experimental Biology, April 20-24, 2002, New Orleans, Louisiana, USAFASEB Journal 16 (4) : A622 March 20, 200229. Klasing, Kirk C.Role for chicken avidin in nutritional immunityAnnual Meeting of the Professional Research Scientists on Experimental Biology, April 20-24, 2002, New Orleans, Louisiana, USAFASEB Journal 16 (4) : A621 March 20, 200230. Humphrey, Brooke D.; Huang, Ning; Klasing, Kirk C.Rice expressing lactoferrin and lysozyme has antibiotic-like properties when fed to chicksJournal of Nutrition 132 (6) : 1214-1218 June, 200231. Leshchinsky, Tatiana V.; Klasing, Kirk C.Divergence of the inflammatory response in two types of chickensDevelopmental and Comparative Immunology 25 (7) : 629-638 September, 200132. Koutsos, Elizabeth A.; Smith, Jeanne; Woods, Leslie W., et al.Adult cockatiels (Nymphicus hollandicus) metabolically adapt to high protein dietsJournal of Nutrition 131 (7) : 2014-2020 July, 200133. Adler, Kevyn L.; Peng, Phyllis H.; Peng, Raymond K., et al.The kinetics of hemopexin and alpha1-acid glycoprotein levels induced by injection of inflammatory agents in chickensAvian Diseases 45 (2) : 289-296 April-June, 200134. Klasing, Kirk C.; Thacker, Paul; Lopez, Melvin A., et al.Increasing the calcium content of mealworms (Tenebrio molitor) to improve their nutritional value for bone mineralization of growing chicksJournal of Zoo and Wildlife Medicine 31 (4) : 512-517 December, 200035. Koutsos, Elizabeth A.; Klasing, Kirk C.The acute phase response in Japanese quail (Coturnix coturnix japonica)Comparative Biochemistry and Physiology Part C Toxicology and Pharmacology 128C (2) : 255-263 February, 200136. Matson, Kevin D.; Millam, James R.; Klasing, Kirk C.Thresholds for sweet, salt, and sour taste stimuli in cockatiels (Nymphicus hollandicus)Zoo Biology 20 (1) : 1-13 200137. Matson, Kevin D.; Millam, James R.; Klasing, Kirk C.Taste threshold determination and side-preference in captive cockatiels (Nymphicus hollandicus)Applied Animal Behaviour Science 69 (4) : 313-326 25 October, 200038. Myers, Merrick R.; Klasing, Kirk C.Low glucokinase activity and high rates of gluconeogenesis contribute to hyperglycemia in barn owls (Tyto alba) after a glucose challengeJournal of Nutrition 129 (10) : 1896-1904 Oct., 199939. Crippen, Tawni L.; Klasing, Kirk C.; Hyde, Dallas M.Regulation of cytokine-induced neutrophil chemoattractant in rat bone marrow-derived macrophages by inflammatory mediatorsPathobiology 66 (6) : 293-301 Nov.-Dec., 199840. Korver, Douglas R.; Klasing, Kirk C.Dietary fish oil alters specific and inflammatory immune responses in chicksJournal of Nutrition 127 (10) : 2039-2046 199741. McCracken, Barbara A.; Gaskins, H. Rex; Ruwe-Kaiser, Pamela J., et al.Diet-dependent and diet-independent metabolic responses underlie growth stasis of pigs at weaningJournal of Nutrition 125 (11) : 2838-2845 199542. Barnes, David M.; Calvert, Christopher C.; Klasing, Kirk C.Methionine deficiency decreases protein accretion and synthesis but not tRNA acylation in muscles of chicksJournal of Nutrition 125 (10) : 2623-2630 199543. Crippen, Tawni L.; Klasing, Kirk C.; Hyde, Dallas M.Cytokine-induced neutrophil chemoattractant production by primary rat alveolar type II cellsInflammation 19 (5) : 575-586 199544. Peng, Raymond K.; Klasing, Kirk C.The recombinant extracellular domain of chicken interleukin-1 (IL-1) receptor neutralizes IL-1 biological activity, in vitroEighty-fourth Annual Meeting of the Poultry Science Association, Inc., August 14-18, 1995, Edmonton, Alberta, CanadaPoultry Science 74 (SUPPL. 1) : 160 199545. Hallquist, Nora Ann; Klasing, Kirk C.Serotransferrin, ovotransferrin and metallothionein levels during an immune response in chickensComparative Biochemistry and Physiology B Comparative Biochemistry and Molecular Biology 108 (3) : 375-384 199446. Klasing, Kirk C.Avian Leukocytic CytokinesPoultry Science 73 (7) : 1035-1043 199447. Roura, Eugeni; Homedes, Josep; Klasing, Kirk C.Prevention of immunologic stress contributes to the growth-permitting ability of dietary antibiotics in chicksJournal of Nutrition 122 (12) : 2383-2390 199248. Roura, Eugeni; Klasing, Kirk C.Dietary antibiotics reduce immunologic stress elicited by poor sanitation or consumption of excreta in broiler chicksEighty-second Annual Meeting of the Poultry Science Association, Inc., July 26-29, 1993, East Lansing, Michigan, USAPoultry Science 72 (SUPPL. 1) : 1 199349. Hallquist, Nora Ann; Klasing, Kirk C.Production of mRNA for serotransferrin and ovotransferrin during an acute-phase immune response of broilers and laying hensMeeting of the Federation of American Societies for Experimental Biology on Experimental Biology '93, March 28-April 1, 1993, New Orleans, Louisiana, USAFASEB Journal 7 (3-4) : A596 1993